Retrospective Probability of Success (PoS) answers “what usually happens across programs.” Apotek Signal answers “what is likely to happen for this asset.” Key Takeaways Apotek Signal quantifies clinical risk at the asset level :  It estimates the probability that a specific trio of drug–target–indication will succeed at a given clinical phase. Phase-aware by design : Separate models for clinical trial phase I, II, and III reflect how decision criteria change across developme